12. Yellowing of Skin and Eyes (Jaundice) or Worsening Jaundice
While jaundice can result from many liver conditions, sudden onset or rapid worsening of jaundice can indicate a tumor blocking bile ducts or causing liver failure. The yellowing of skin and eyes occurs as bilirubin accumulates in tissues.
New jaundice in someone without previous liver disease is always concerning and requires immediate investigation. In patients with existing jaundice, sudden worsening despite stable disease suggests new pathology—potentially a malignancy. This symptom demands urgent imaging and possible specialist consultation.
11. Unexplained Fever
A persistent low-grade fever (100-101°F) without obvious infection can accompany advanced liver cancer. The tumor triggers systemic inflammation and immune responses, producing fever as a paraneoplastic syndrome.
This fever doesn’t respond to antibiotics and persists despite no signs of infection on laboratory tests. If you experience unexplained, persistent fever, especially combined with other concerning symptoms, malignancy should be considered. Blood cultures and imaging may be needed to rule out infection versus cancer-related fever.
10. Loss of Appetite and Early Satiety
Beyond appetite loss from general liver disease, a growing tumor can cause mechanical obstruction or release appetite-suppressing substances. Patients often report feeling full after eating very small amounts.
This differs from typical appetite loss by being accompanied by a sensation of abdominal fullness or pressure. Food that previously seemed appealing becomes undesirable. Combined with weight loss, this represents a significant warning sign. If appetite loss is accompanied by progressive weight loss and abdominal symptoms, tumor development should be investigated.
9. Nausea and Vomiting
Persistent nausea and vomiting can result from the tumor producing toxic substances or from increased intracranial pressure if the cancer has metastasized. Unlike nausea from gastroenteritis, cancer-related nausea is chronic and unrelenting.
Vomiting may be projectile or contain blood if esophageal varices develop or the tumor invades blood vessels. If you experience persistent vomiting, especially when combined with other symptoms, this is concerning. Imaging and laboratory studies are essential to determine the cause.
